Simone Fattal was born in Damascus, Syria, and raised in Lebanon, where she studied philosophy at the "Ecole des Lettres" in Beirut. She then moved to Paris, where she continued her philosophical pursuits at the Sorbonne. In 1969 she returned to Beirut and began working as a visual artist, exhibiting her paintings until the start of the Lebanese Civil War. She left Lebanon in 1980 and settled in California, where she founded the "Post-Apollo Press", a publishing house dedicated to innovative and experimental literary work. In 1988 she enrolled at the "Art Institute of San Francisco", which prompted a return to her artistic practice and a newfound dedication to sculpture and ceramics.

Fattal currently lives in Paris. Among her recent solo exhibitions: Aichi Triennial Japan (2025); Istanbul Biennial (2025); Musée du Louvre, Paris (2024); Secession, Vienna (2024); IVAM, Valencia (2024); Portikus, Frankfurt (2023); KINDL, Berlin (2023); Ocean Space, Venice (2023); Sharjah Art Foundation, Sharjah (2023); La Biennale di Venezia, Venice (2022); 16th Lyon Biennale, Lyon (2022); 12th Berlin Biennale, Berlin (2022); Whitechapel Gallery, London (2021); MoMA PS1, New York (2019).