Samy Moussa has regularly collaborated with several orchestras and ensembles: Radio Symphonieorchester Wien, Sinfonieorchester des Bayerischen Rundfunks, Deutsches Symphonie-Orchester Berlin, Sinfonieorchester des Mitteldeutschen Rundfunks Leipzig, Radio-Sinfonie-Orchester Frankfurt, Orchester symphonique de Montreal, CBC Radio Orchestra Vancouver, Lorraine National Orchestra, Hamilton Philharmonic Orchestra and Vancouver Symphony Orchestra. In 2010, Samy Moussa was appointed Music Director of the INDEX Ensemble in Munich.

Vastation, his second opera, on a libretto by the writer Toby Litt, was premiered at the Munich Biennale in 2014, under the direction of the composer, with the Philharmonisches Orchester Regensburg and was taken over in Regensburg. His first opera, The Other Brother, was premiered at the 12th Munich Biennial in 2010. His orchestral works are defended by renowned musicians such as Kent Nagano, who commissioned him five orchestral pieces for the Symphony Orchestra Montreal, including A Globe Itself Infolding for Organ and Orchestra (2014) or, most recently, Symphony No. 1 Concordia (2016-17). His music is known for his clarity and power as well as his refined orchestration, his art of direction is characterized by an energetic and inspired style.

Samy Moussa participated in masterclasses of conducting with Pierre Boulez and Peter Eötvös. He studied composition and conducting at the Université de Montréal with José Evangelista as principal professor. In parallel, he was taking management courses in the Czech Republic with Paolo Bellomia. He has been invited to study in Finland with Magnus Lindberg and Kaija Saariaho as part of the International Summer Sounds Festival. In 2007, Samy Moussa moved to Germany where he enrolled at the Hochschule für Musik und Theater München and studied with Matthias Pintscher and Pascal Dusapin. He also takes lessons from Salvatore Sciarrino at the Voix Nouvelles de Royaumont.

Samy Moussa was assistant conductor of the Frankfurt Symphony Orchestra and Ensemble Modern. He received the Bayerischen Kunstförderpreis 2012 for his work with the INDEX Ensemble and was awarded the Composer's Prize 2013 by the Ernst von Siemens Music Foundation. He was declared "Composer of the Year" in Quebec in 2015, when Pierre Boulez commissioned a new orchestral piece - Crimson - for the Lucerne Festival 2015. In 2017, he received the Hindemithn Prize, a prize he receives from Christoph Eschenbach.

Samy Moussa lives in Paris and Berlin. His music is published by Durand Publishing (Universal Music Publishing Classical).